Measures to Prevent and Control Transmission of Multidrug-Resistant Gram-Negative Bacilli (Excluding Carbapenemase-Producing Enterobacteriaceae) in Acute Care Settings in Québec

Gram-negative bacilli (GNB) are bacteria frequently encountered in clinical settings, both as normal flora and as pathogens in a variety of infections.

The use of antibiotics has led to the emergence of various resistance mechanisms and some of these bacteria are now resistant to several classes of antibiotics.

This document was created to help healthcare-associated infection prevention and control (IPC) teams identify major multidrug-resistant. Gram-negative bacilli (MDR-GNB) and implement IPC measures to prevent them from being transmitted to acute care settings in Québec. This document replaces the document published in 2015 and discusses all GNB excluding carbapenemase-producing Enterobacteriaceae (CPE). Since the latter are important, a separate document has been created containing the information that pertains to them (CINQ 2017).

This document is primarily intended to be used as a basic reference for centres that are not dealing with an outbreak. While the measures to be implemented in the case of an outbreak are often mentioned in the literature, few articles discuss the measures to be taken to avoid transmission of MDR-GNB (excluding CPEs) outside such a context. The following recommendations are therefore based in large part on the opinion of the working group, the collaborators and the members of the Comité sur les infections nosocomiales du Québec (CINQ) [Québec healthcare-associated infections committee]. The recommendations take the current data into account and should be revised to reflect changes in the epidemiology and knowledge on the reservoirs and on transmission.

In addition to the specific measures, routine IPC practices, in particular hand hygiene, play an important role in preventing transmission of multidrug-resistant bacteria. The best practices of the Programme québécois des soins sécuritaires [Québec safe care program] are an important tool for controlling infections caused by these bacteria (INSPQ, 2018). Antibiotic stewardship also plays an important role, by limiting exposure of bacteria to antibiotics and by avoiding the selection of resistant bacteria, since antibiotic use is the main risk factor for bacteria acquiring resistance.

Measures to Prevent and Control Transmission of Multidrug-Resistant Gram-Negative Bacilli (Excluding Carbapenemase-Producing Enterobacteriaceae) in Acute Care Settings in Québec
Types of Publication
ISBN (Digital)
978-2-550-81783-3
Santecom Number
Date de publication