Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis Sequence Type-11 clonal complex isolates associated with invasive meningococcal disease

OBJECTIVE: We analyzed the Canadian invasive MenW ST-11 cc isolates by whole genome typing and compared Canadian isolates with similar isolates elsewhere. METHODS: Whole genome typing of 30 MenW ST-11 cc, 20 meningococcal group C (MenC) ST-11 cc and 31 MenW ST-22 cc isolates were carried out on the Bacterial Isolate Genome Sequence database platform. Canadian MenW ST-11 cc isolates were compared with the 2000 MenW Hajj outbreak strain, as well as with MenW ST-11 cc from other countries. RESULTS: Whole genome typing showed that the Canadian MenW ST-11 cc isolates were distinct from the traditional MenW ST-22 cc; they were not capsule switched contemporary MenC strains that incorporated MenW capsules. While some recent MenW disease cases in Canada were caused by MenW ST-11 cc isolates showing relatedness to the 2000 MenW Hajj strain, many were non-Hajj isolates similar to current MenW ST-11 isolates found globally. Geographical and temporal variations in genotypes and surface protein antigen genes were found among the MenW ST-11 cc isolates. CONCLUSION: The current MenW ST-11 isolates did not arise by capsule switching from contemporary MenC ST-11 isolates, Both the Hajj-related and non-Hajj MenW ST-11 cc strains were associated with IMD in Canada.
Auteurs (Zotero)
Tsang, Raymond S. W.; Ahmad, Tauqeer; Tyler, Shaun; Lefebvre, Brigitte; Deeks, Shelley L.; Gilca, Rodica; Hoang, Linda; Tyrrell, Gregory; Van Caeseele, Paul; Van Domselaar, Gary; Jamieson, Frances B.
Date de publication (Zotero)
février, 2018